On the heels of statement victories Week 1, Justin Herbert’s Los Angeles Chargers head to Kansas City to face Patrick Mahomes and the Chiefs, who have owned the last six AFC West titles.
Herbert and Mahomes put up a combined eight passing touchdowns for wins over the Las Vegas Raiders and Arizona Cardinals, respectively. The talented quarterbacks duel Thursday at Arrowhead Stadium. Kickoff is set for 8:15 p.m. ET on Amazon Prime.
Though it’s still early in the season, could first place in the AFC West be on the line with this matchup? Can Khalil Mack and the Chargers’ defense contain Kansas City’s attack? 
Here’s a look at the betting details and USA TODAY’s NFL staff picks for Chargers vs. Chiefs:
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Chiefs vs. Chargers | Jets vs. Browns | Buccaneers vs. Saints | Panthers vs. Giants | Patriots vs. Steelers | Seahawks vs. 49ers | Falcons vs. Rams | Cardinals vs. Raiders | Texans vs. Broncos | Bears vs. Packers | Titans vs. Bills | Vikings vs. Eagles
This is a fascinating matchup, and while I’m big on L.A.’s prospects for the rest of this season, the Chiefs are a tough out — especially at home. The Chargers are still susceptible to some volatility, so Kansas City, in prime time, early in the season, makes sense.
Patrick Mahomes and the Chiefs are going to score 40+ points for the second straight game. Kansas City did not miss a beat without Tyreek Hill and has so many diverse weapons to account for that it feels like the offense has no weaknesses. Justin Herbert will miss star receiver Keenan Allen (hamstring) in this one.
A Thursday night road game has historically been a daunting challenge. Add in that add a raucous Arrowhead Stadium, Patrick Mahomes coming off a comfortable thrashing of Arizona and Chargers receiver Keenan Allen’s injury, Los Angeles can shrug off this one and plot to win the Nov. 20 rematch at home.
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